U.S. Secretary of State John Kerry said a speech by Iranian Supreme Leader Ali Khamenei on Saturday vowing to defy American policies in the region despite a deal with world powers over Tehran's nuclear program was "very disturbing". Ayatollah Khamenei told supporters on Saturday that U.S. policies in the region were "180 degrees" opposed to Iran's, at a speech in a Tehran mosque punctuated by chants of "Death to America" and "Death to Israel". "Even after this deal our policy toward the arrogant U.S. will not change," Khamenei said.